The RADIL has a primary research mission of investigating diseases in research animals. Significant outcomes of these disease studies include identification and characterization of newly-recognized disease agents, description of animal models of human disease and development of state-of-the-art diagnostic tests to identify rodent disease agents that would adversely affect animal-based research. The combined activiities of the RADIL research and diagnostic laboratories naturally provide an enriched environment for training of veterinary residents and graduate students.
11.19.2009
In the past, in order to accurately determine the presence of pinworms in an animal has required a post-mortem direct exam. With the introduction of RADIL's new PCR assay which tests for both Syphacia obvelata and Aspiculuris tetraptera, antemortem testing can now be performed with highly accurate results. RADIL's Pinworm PCR assay is nearly as sensitive as the direct exam and has the advantage that the animal does not need to be euthanized for evaluation. In studies, it was also more sensitive than either of the two antemortem tests (tape test and fecal float).
Pinworm by PCR evaluation will be available beginning December 1, 2009 as part of the Mouse Basic , Mouse Comprehensive and Rat Basic Fecal Panels, as a Helicobacter & Pinworm panel, or as a stand-alone assay. For more information and pricing, please click here.
( for more info click here )11.19.2009
At this year's National AALAS Meeting in Denver, Colorado, RADIL 
introduced a breakthrough serologic testing technology that will offer clients an increased level of results confidence for the most prevalent mouse and rat agents. MFI2 represents an advanced approach to serologic monitoring for laboratory animal pathogens, providing the highest level of diagnostic accuracy available. By evaluating multiple antigens for each agent, primary and confirmatory testing now occur at the same time, saving time and increasing the predictive value of the final results. Clients will begin seeing multiple antigens reported on case reports as of December 1, 2009.
For more information regarding MFI2, please visit the Serology section of this site.
( for more info click here )Spindler RE, Crichton EG, Agca Y, Loskutoff N, Critser JK, Gardner DK, Wildt DE. Improved felid embryo development by group culture is maintained with heterospecific companions. Theriogenology. 2006 Jul 1;66(1):82-92. Epub 2006 Apr 27.
Lu Q, Zhao Y, Gao X, Li Y, Ma S, Mullen S, Critser JK, Chen ZJ. Combination of calcium ionophore A23187 with puromycin salvages human unfertilized oocytes after ICSI. Eur J Obstet Gynecol Reprod Biol. 2006 May 1;126(1):72-6. Epub 2005 Dec 13.
Jiao A, Han X, Critser JK, Ma H. Numerical investigations of transient heat transfer characteristics and vitrification tendencies in ultra-fast cell cooling processes. Cryobiology. 2006 Apr 5
Li Y, Feng HL, Cao YJ, Zheng GJ, Yang Y, Mullen S, Critser JK, Chen ZJ. Confocal microscopic analysis of the spindle and chromosome configurations of human oocytes matured in vitro. Fertil Steril. 2006 Apr;85(4):827-32.
Benson JD, Haidekker MA, Benson CM, Critser JK. Mercury free operation of the Coulter counter MultiSizer II sampling stand. Cryobiology. 2005 Dec;51(3):344-7. Epub 2005 Sep 27.
Men H, Agca Y, Critser ES, Critser JK. Beneficial effects of serum supplementation during in vitro production of porcine embryos on their ability to survive cryopreservation by open pulled straw vitrification. Theriogenology. 2005 Oct 1;64(6):1340-9. Epub 2005 Apr 12
Men H, Agca Y, Mullen SF, Critser ES, Critser JK. Osmotic tolerance of in vitro produced porcine blastocysts assessed by their morphological integrity and cellular actin filament organization. Cryobiology. 2005 Oct;51(2):119-29.
Agca Y, Mullen S, Liu J, Johnson-Ward J, Gould K, Chan A, Critser J. Osmotic tolerance and membrane permeability characteristics of rhesus monkey (Macaca mulatta) spermatozoa. Cryobiology. 2005 Aug;51(1):1-14.
Agca Y, Liu J, Mullen S, Johnson-Ward J, Gould K, Chan A, Critser J. Chimpanzee (Pan troglodytes) spermatozoa osmotic tolerance and cryoprotectant permeability characteristics. J Androl. 2005 Jul-Aug;26(4):470-7.
Benson JD, Chicone CC, Critser JK. Exact solutions of a two parameter flux model and cryobiological applications. Cryobiology. 2005 Jun;50(3):308-16.
Walters EM, Men H, Agca Y, Mullen SF, Critser ES, Critser JK. Osmotic tolerance of mouse spermatozoa from various genetic backgrounds: acrosome integrity, membrane integrity, and maintenance of motility. Cryobiology. 2005 Apr;50(2):193-205.
Lakey JR, Woods EJ, Zieger MA, Avila JG, Geary WA, Voytik-Harbin SL, Critser JK. Improved islet survival and in vitro function using solubilized small intestinal submucosa. Cell Tissue Bank. 2001;2(4):217-24.
Woods EJ, Walsh CM, Sidner RA, Zieger MA, Lakey JR, Ricordi C, Critser JK. Improved in vitro function of islets using small intestinal submucosa. Transplant Proc. 2004 May;36(4):1175-7.
Woods EJ, Walsh CM, Sidner RA, Zieger MA, Mullin S, Lakey JR, Ricordi C, Critser JK. Enhanced recovery of cryopreserved islets using SIS. Transplant Proc. 2004 May;36(4):1139-42.
Woods EJ, Benson JD, Agca Y, Critser JK. Fundamental cryobiology of reproductive cells and tissues. Cryobiology. 2004 Apr;48(2):146-56. Review.
Mullen SF, Agca Y, Broermann DC, Jenkins CL, Johnson CA, Critser JK. The effect of osmotic stress on the metaphase II spindle of human oocytes, and the relevance to cryopreservation. Hum Reprod. 2004 May;19(5):1148-54. Epub 2004 Apr 7.
Mullen SF, Critser JK. Using TUNEL in combination with an active caspase-3 immunoassay to identify cells undergoing apoptosis in preimplantation Mammalian embryos. Methods Mol Biol. 2004;254:393-406
Mullen SF, Critser JK. Immunocytochemical staining of the metaphase II spindle in mammalian oocytes. Methods Mol Biol. 2004;253:201-13.
Chaveiro A, Liu J, Mullen S, Woelders H, Critser JK. Determination of bull sperm membrane permeability to water and cryoprotectants using a concentration-dependent self-quenching fluorophore. Cryobiology. 2004 Feb;48(1):72-80.
Woods EJ, Liu J, Pollok K, Hartwell J, Smith FO, Williams DA, Yoder MC, Critser JK. A theoretically optimized method for cord blood stem cell cryopreservation. J Hematother Stem Cell Res. 2003 Jun;12(3):341-50.
Guthrie HD, Liu J, Critser JK. Osmotic tolerance limits and effects of cryoprotectants on motility of bovine spermatozoa. Biol Reprod. 2002 Dec;67(6):1811-6.
Agca Y, Gilmore J, Byers M, Woods EJ, Liu J, Critser JK. Osmotic characteristics of mouse spermatozoa in the presence of extenders and sugars. Biol Reprod. 2002 Nov;67(5):1493-501.
Liu J, Christian JA, Critser JK. Canine RBC osmotic tolerance and membrane permeability. Cryobiology. 2002 Jun;44(3):258-68.
Agca Y, Critser JK. Cryopreservation of spermatozoa in assisted reproduction. Semin Reprod Med. 2002 Feb;20(1):15-23.
Keskintepe L, Agca Y, Pacholczyk GA, Machnicka A, Critser JK. Use of cryopreserved pronuclear embryos for the production of transgenic mice. Biol Reprod. 2001 Aug;65(2):407-11.
©2007 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information.
An equal opportunity/affirmative action institution.
design provided by Nine Plus One