The RADIL has a primary research mission of investigating diseases in research animals. Significant outcomes of these disease studies include identification and characterization of newly-recognized disease agents, description of animal models of human disease and development of state-of-the-art diagnostic tests to identify rodent disease agents that would adversely affect animal-based research. The combined activiities of the RADIL research and diagnostic laboratories naturally provide an enriched environment for training of veterinary residents and graduate students.
11.19.2009
In the past, in order to accurately determine the presence of pinworms in an animal has required a post-mortem direct exam. With the introduction of RADIL's new PCR assay which tests for both Syphacia obvelata and Aspiculuris tetraptera, antemortem testing can now be performed with highly accurate results. RADIL's Pinworm PCR assay is nearly as sensitive as the direct exam and has the advantage that the animal does not need to be euthanized for evaluation. In studies, it was also more sensitive than either of the two antemortem tests (tape test and fecal float).
Pinworm by PCR evaluation will be available beginning December 1, 2009 as part of the Mouse Basic , Mouse Comprehensive and Rat Basic Fecal Panels, as a Helicobacter & Pinworm panel, or as a stand-alone assay. For more information and pricing, please click here.
( for more info click here )11.19.2009
At this year's National AALAS Meeting in Denver, Colorado, RADIL 
introduced a breakthrough serologic testing technology that will offer clients an increased level of results confidence for the most prevalent mouse and rat agents. MFI2 represents an advanced approach to serologic monitoring for laboratory animal pathogens, providing the highest level of diagnostic accuracy available. By evaluating multiple antigens for each agent, primary and confirmatory testing now occur at the same time, saving time and increasing the predictive value of the final results. Clients will begin seeing multiple antigens reported on case reports as of December 1, 2009.
For more information regarding MFI2, please visit the Serology section of this site.
( for more info click here )Bauer BA, Riley LK. Antemortem detection of mouse parvovirus and mice minute virus by polymerase chain reaction (PCR) of faecal samples. Lab Anim. 2006 Apr;40(2):144-52.
Wan CH, Bauer BA, Pintel DJ, Riley LK. Detection of rat parvovirus type 1 and rat minute virus type 1 by polymerase chain reaction. Lab Anim. 2006 Jan;40(1):63-9.
Hsu CC, Wobus CE, Steffen EK, Riley LK, Livingston RS. Development of a microsphere-based serologic multiplexed fluorescent immunoassay and a reverse transcriptase PCR assay to detect murine norovirus 1 infection in mice. Clin Diagn Lab Immunol. 2005 Oct;12(10):1145-51.
Gupta GD, Lakritz J, Saville WJ, Livingston RS, Dubey JP, Middleton JR, Marsh AE. Antigenic evaluation of a recombinant baculovirus-expressed Sarcocystis neurona SAG1 antigen. J Parasitol. 2004 Oct;90(5):1027-33.
Bauer BA, Besch-Williford CL, Riley LK. Comparison of the mouse antibody production (MAP) assay and polymerase chain reaction (PCR) assays for the detection of viral contaminants. Biologicals. 2004 Dec;32(4):177-82.
Livingston, RS, L.K. Riley. Diagnostic testing of mouse and rat colonies for infectious agents. Lab. Animal. 2003 May: 32(5):44-51.
Kendall LV, Riley LK. Flow cytometry. Contemp Top Lab Anim Sci. 2002 Sep;41(5):50.
Livingston RS, Besselsen DG, Steffen EK, Besch-Williford CL, Franklin CL, Riley LK. Serodiagnosis of mice minute virus and mouse parvovirus infections in mice by enzyme-linked immunosorbent assay with baculovirus-expressed recombinant VP2 proteins. Clin Diagn Lab Immunol. 2002 Sep;9(5):1025-31.
Drazenovich NL, Franklin CL, Livingston RS, Besselsen DG. Detection of rodent Helicobacter spp. by use of fluorogenic nuclease polymerase chain reaction assays. Comp Med. 2002 Aug;52(4):347-53.
Wan CH, Soderlund-Venermo M, Pintel DJ, Riley LK. Molecular characterization of three newly recognized rat parvoviruses. J Gen Virol. 2002 Aug;83(Pt 8):2075-83.
Kendall LV, Franklin CL, Riley LK. Immunohistochemistry. Contemp Top Lab Anim Sci. 2001 May;40(3):43
Carty AJ, Franklin CL, Riley LK, Besch-Williford CL. Diagnostic polymerase chain reaction assays for identification of murine polyomaviruses in biological samples. Comp Med. 2001 Apr;51(2):145-9.
MFI Publications by RADIL
Hsu, CC Franklin CL, and Riley LK. Multiplex Fluorescent Immunoassay. Lab Animal. 7; 27-30, 2007.
Hsu, CC Franklin CL, and Riley LK. Multiplex Immunoassay for the Simultaneous Detection of Serum Antibodies to Muliple Rodent Pathogens. Lab Animal Europe, 7:27-30, 2007.
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