The RADIL has a primary research mission of investigating diseases in research animals. Significant outcomes of these disease studies include identification and characterization of newly-recognized disease agents, description of animal models of human disease and development of state-of-the-art diagnostic tests to identify rodent disease agents that would adversely affect animal-based research. The combined activiities of the RADIL research and diagnostic laboratories naturally provide an enriched environment for training of veterinary residents and graduate students.
11.19.2009
In the past, in order to accurately determine the presence of pinworms in an animal has required a post-mortem direct exam. With the introduction of RADIL's new PCR assay which tests for both Syphacia obvelata and Aspiculuris tetraptera, antemortem testing can now be performed with highly accurate results. RADIL's Pinworm PCR assay is nearly as sensitive as the direct exam and has the advantage that the animal does not need to be euthanized for evaluation. In studies, it was also more sensitive than either of the two antemortem tests (tape test and fecal float).
Pinworm by PCR evaluation will be available beginning December 1, 2009 as part of the Mouse Basic , Mouse Comprehensive and Rat Basic Fecal Panels, as a Helicobacter & Pinworm panel, or as a stand-alone assay. For more information and pricing, please click here.
( for more info click here )11.19.2009
At this year's National AALAS Meeting in Denver, Colorado, RADIL 
introduced a breakthrough serologic testing technology that will offer clients an increased level of results confidence for the most prevalent mouse and rat agents. MFI2 represents an advanced approach to serologic monitoring for laboratory animal pathogens, providing the highest level of diagnostic accuracy available. By evaluating multiple antigens for each agent, primary and confirmatory testing now occur at the same time, saving time and increasing the predictive value of the final results. Clients will begin seeing multiple antigens reported on case reports as of December 1, 2009.
For more information regarding MFI2, please visit the Serology section of this site.
( for more info click here )Franklin CL. Microbial considerations in genetically engineered mouse research. ILAR J. 2006;47(2):141-55.
Spier AW, Toth LA, Faingold CA, Franklin CL. Clinical patent ductus arteriosus in adult genetically epilepsy-prone rats. Comp Med. 2005 Feb;55(1):85-91
Pfeiffer BJ, Franklin CL, Hsieh FH, Bank RA, Phillips CL. Alpha 2(I) collagen deficient oim mice have altered biomechanical integrity, collagen content, and collagen crosslinking of their thoracic aorta. Matrix Biol. 2005 Oct;24(7):451-8. Epub 2005 Aug 10.
Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1050-8. Epub 2004 Jan 8.
Curran EM, Judy BM, Newton LG, Lubahn DB, Rottinghaus GS, MacDonald RS, Franklin CL, Estes DM. Dietary soy phytoestrogens and ERalpha signaling modulate interferon gamma production to bacterial infection. Clin. Exp. Immunol.. 135:219-25, 2004
Gawenis LR, Franklin CL, Simpson JE, Palmer BA, Walker NM, Wiggins TM, Clarke LL. cAMP inhibition of murine intestinal Na/H exchange requires CFTR-mediated cell shrinkage of villus epithelium. Gastroenterology. 2003 Oct;125(4):1148-63.
Alworth LC, Howdeshell KL, Ruhlen RL, Day JK, Lubahn DB, Huang TH, Besch-Williford CL, vom Saal FS. Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: effects of low versus high doses. Toxicol Appl Pharmacol. 2002 Aug 15;183(1):10-22
Carter DB, Lai L, Park KW, Samuel M, Lattimer JC, Jordan KR, Estes DM, Besch-Williford C, Prather RS. Phenotyping of transgenic cloned piglets. Cloning Stem Cells. 2002;4(2):131-45.
Day JK, Bauer AM, DesBordes C, Zhuang Y, Kim BE, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang TH, Lubahn DB. Genistein alters methylation patterns in mice. J Nutr. 2002 Aug;132(8 Suppl):2419S-2423S.
Phillips CL, Pfeiffer BJ, Luger AM, Franklin CL. Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim). Kidney Int. 2002 Aug;62(2):383-91.
Day JK, Besch-Williford C, McMann TR, Hufford MG, Lubahn DB, MacDonald RS. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Cancer. 2001;39(2):226-32.
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